Safety of nonselective nonsteroidal anti-inflammatory drugs in cardiac surgery: a historical cohort study.

Journal: Canadian journal of anaesthesia = Journal canadien d'anesthesie
Published Date: Jun 25, 2025

Abstract

PURPOSE: Pain management after cardiac surgery is imperative, as inadequate analgesia can increase the risk of myocardial ischemia, thromboembolism, and pulmonary complications. Nonsteroidal anti-inflammatory drugs (NSAIDs) are an important component of multimodal analgesia, but their use in the postoperative cardiac surgery population is controversial owing to concerns of acute kidney injury (AKI), thrombotic events, and bleeding. We aimed to evaluate the rate of AKI, major adverse cardiovascular events (MACE), and major bleeding in patients receiving NSAIDs early after cardiac surgery.

Authors

  • Tyson Miao
    Department of Pharmacy, Surrey Memorial Hospital, 13750 96 Ave, Surrey, BC, V3V 1Z2, Canada. tyson.miao@fraserhealth.ca.
  • Lik Hang N Lee
    Department of Psychiatry, University of Alberta, Edmonton, AB, Canada.
  • Terri Sun
    Department of Anesthesia, St. Paul's Hospital, Providence Health Care, Vancouver, BC, Canada.
  • Megan Patapoff
    Ambulatory Cardiology, Vancouver General Hospital, Vancouver, BC, Canada.
  • Erica Wang
    Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, Canada.

Keywords

No keywords available for this article.

External Resources

Popular Topics
Recent Journals