Development and validation of a combined clinical and MRI-based biomarker model to differentiate mild cognitive impairment from mild Alzheimer's disease.

Journal: PCN reports : psychiatry and clinical neurosciences
Published Date: Jun 26, 2025

Abstract

BACKGROUND: Two of the most common complaints seen in neurology clinics are Alzheimer's disease (AD) and mild cognitive impairment (MCI), characterized by similar symptoms. The aim of this study was to develop and internally validate the diagnostic value of combined neurological and radiological predictors in differentiating mild AD from MCI as the outcome variable, which helps in preventing AD development.

Authors

  • Zohreh Hosseini
    Department of Psychiatry Tehran University of Medical Sciences Tehran Iran.
  • Alisa Mohebbi
    Students' Scientific Research Center Tehran University of Medical Sciences Tehran Iran.
  • Iman Kiani
    Students' Scientific Research Center Tehran University of Medical Sciences Tehran Iran.
  • Aydin Taghilou
    Adl Hospital Tehran Iran.
  • Atefeh Mohammadjafari
    Psychiatry, School of Medicine Tehran University of Medical Sciences Tehran Iran.
  • Vajiheh Aghamollaii
    Neurology Department, Roozbeh Hospital Tehran University of Medical Sciences Tehran Iran.

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