Deep Learning MRI Models for the Differential Diagnosis of Tumefactive Demyelination versus Wild-Type Glioblastoma.

Journal: AJNR. American journal of neuroradiology
Published Date:

Abstract

BACKGROUND AND PURPOSE: Diagnosis of tumefactive demyelination can be challenging. The diagnosis of indeterminate brain lesions on MRI often requires tissue confirmation via brain biopsy. Noninvasive methods for accurate diagnosis of tumor and nontumor etiologies allows for tailored therapy, optimal tumor control, and a reduced risk of iatrogenic morbidity and mortality. Tumefactive demyelination has imaging features that mimic wild-type glioblastoma (wt GBM). We hypothesized that deep learning applied to postcontrast T1-weighted (T1C) and T2-weighted (T2) MRI can discriminate tumefactive demyelination from wt GBM.

Authors

  • Gian Marco Conte
    Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
  • Mana Moassefi
    Mayo Clinic Artificial Intelligence Lab, Department of Radiology, Mayo Clinic, 200 1st Street, S.W., Rochester, MN, 55905, USA.
  • Paul A Decker
    Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 55905, USA.
  • Matthew L Kosel
    Deptartment of Quantitative Health Sciences (P.A.D., M.L.K., J.E.E.-P.), Mayo Clinic, Rochester, Minnesota.
  • Christina B McCarthy
    Department of Neurology (C.B.M., J.A.S., M.W.R., F.S.G., H.K.P., D.H.L., W.O.T.), Mayo Clinic, Rochester, Minnesota.
  • Jessica A Sagen
    Department of Neurology (C.B.M., J.A.S., M.W.R., F.S.G., H.K.P., D.H.L., W.O.T.), Mayo Clinic, Rochester, Minnesota.
  • Yalda Nikanpour
    From the Department of Radiology (G.M.C., M.M., Y.N., B.J.E.), Mayo Clinic, Rochester, Minnesota.
  • Mahboubeh Fereidan-Esfahani
    Dell Medical School (M.F.-E.), University of Texas, Austin, Texas.
  • Michael W Ruff
    Department of Neurology (C.B.M., J.A.S., M.W.R., F.S.G., H.K.P., D.H.L., W.O.T.), Mayo Clinic, Rochester, Minnesota.
  • Fiorella S Guido
    Department of Neurology (C.B.M., J.A.S., M.W.R., F.S.G., H.K.P., D.H.L., W.O.T.), Mayo Clinic, Rochester, Minnesota.
  • Heather K Pump
    Department of Neurology (C.B.M., J.A.S., M.W.R., F.S.G., H.K.P., D.H.L., W.O.T.), Mayo Clinic, Rochester, Minnesota.
  • Terry C Burns
    Department of Neurosurgery (T.C.B.), Mayo Clinic, Rochester, Minnesota.
  • Robert B Jenkins
    From the Departments of Radiology (G.M.C., K.A.P., J.C.C., B.J.E.), Neurology (D.H.L., W.O.T.), Laboratory Medicine and Pathology (R.B.J.), and Health Sciences Research (J.E.E.P.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; Department of Health Sciences Research, Mayo Clinic, Jacksonville, Fla (A.D.W.); Mayo Clinic Alix School of Medicine, Rochester, Minn (D.C.V.); Neuroradiology Unit, Scientific Institute for Research, Hospitalization, and Healthcare San Raffaele Scientific Institute, Milan, Italy (M.B.); and Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy (F.S.).
  • Bradley J Erickson
    Department of Radiology, Radiology Informatics Lab, Mayo Clinic, Rochester, MN 55905, United States.
  • Daniel H Lachance
    From the Departments of Radiology (G.M.C., K.A.P., J.C.C., B.J.E.), Neurology (D.H.L., W.O.T.), Laboratory Medicine and Pathology (R.B.J.), and Health Sciences Research (J.E.E.P.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; Department of Health Sciences Research, Mayo Clinic, Jacksonville, Fla (A.D.W.); Mayo Clinic Alix School of Medicine, Rochester, Minn (D.C.V.); Neuroradiology Unit, Scientific Institute for Research, Hospitalization, and Healthcare San Raffaele Scientific Institute, Milan, Italy (M.B.); and Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy (F.S.).
  • W Oliver Tobin
    From the Departments of Radiology (G.M.C., K.A.P., J.C.C., B.J.E.), Neurology (D.H.L., W.O.T.), Laboratory Medicine and Pathology (R.B.J.), and Health Sciences Research (J.E.E.P.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; Department of Health Sciences Research, Mayo Clinic, Jacksonville, Fla (A.D.W.); Mayo Clinic Alix School of Medicine, Rochester, Minn (D.C.V.); Neuroradiology Unit, Scientific Institute for Research, Hospitalization, and Healthcare San Raffaele Scientific Institute, Milan, Italy (M.B.); and Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy (F.S.).
  • Jeanette E Eckel-Passow
    From the Departments of Radiology (G.M.C., K.A.P., J.C.C., B.J.E.), Neurology (D.H.L., W.O.T.), Laboratory Medicine and Pathology (R.B.J.), and Health Sciences Research (J.E.E.P.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; Department of Health Sciences Research, Mayo Clinic, Jacksonville, Fla (A.D.W.); Mayo Clinic Alix School of Medicine, Rochester, Minn (D.C.V.); Neuroradiology Unit, Scientific Institute for Research, Hospitalization, and Healthcare San Raffaele Scientific Institute, Milan, Italy (M.B.); and Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy (F.S.).

Keywords

No keywords available for this article.