DNA methylation as a diagnostic biomarker for rheumatoid arthritis: a validation study using targeted sequencing.

Journal: Epigenomics
Published Date:

Abstract

OBJECTIVES: To validate the potential of the serotonin receptor encoded by 5-hydroxytryptamine receptor 2A (HTR2A) cg15692052 DNA methylation as a diagnostic biomarker for rheumatoid arthritis (RA) and its subtypes.

Authors

  • Jianan Zhao
    Department of Rheumatology, Shanghai Guanghua Hospital of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Binghen He
    Shuguang Clinical Medical College, Shanghai University of Traditional Chinese Medicine Affiliated Shuguang Hospital, Shanghai, China.
  • Yunshen Li
    Department of Rheumatology, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Yu Shan
  • Kai Wei
    School of Electrical and Electronic Engineering, Harbin University of Science and Technology, Harbin 150080, China.
  • Ping Jiang
    School of Automation, Huazhong University of Science and Technology, Wuhan 430074, China; School of Computer Science and Technology, Hubei PolyTechnic University, Huangshi 435003, China. Electronic address: jiangping20140209@gmail.com.
  • Yiming Shi
    Department of Rheumatology, Shanghai Guanghua Hospital of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Yixin Zheng
    Department of Rheumatology, Shanghai Guanghua Hospital of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Fuyu Zhao
    Department of Rheumatology, Shanghai Guanghua Hospital of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Guizhen Yang
    The Research Center for Traditional Chinese Medicine, Shanghai Institute of Infectious Diseases and Biosecurity, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Qianqian Li
    Northwestern Polytechnical University, 127 West Youyi Road, Xi'an, 710072, China.
  • Mi Zhou
    The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangzhou, China.
  • Shicheng Guo
    Center for Human Genetics, Marshfield Clinic Research Foundation, 9500 Gilman Drive, MC0412, Marshfield, Wisconsin 54449 United States.
  • Yuejuan Zheng
    The Research Center for Traditional Chinese Medicine, Shanghai Institute of Infectious Diseases and Biosecurity, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Juan Jiao
    Clinical Lab, The Seventh Medical Center of Chinese People's Liberation Army General Hospital, Beijing 100700, China.
  • Rongsheng Wang
    Macao Polytechnic university, Faculty of Applied Sciences, Macau, China.
  • Cen Chang
    Department of Rheumatology, Shanghai Guanghua Hospital of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Liangjing Lv
    Department of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Keywords

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