Patient-specific deep learning tracking for real-time 2D pancreas localisation in kV-guided radiotherapy.

Journal: Physics and imaging in radiation oncology
Published Date: Jun 6, 2025

Abstract

BACKGROUND AND PURPOSE: In pancreatic stereotactic body radiotherapy (SBRT), accurate motion management is crucial for the safe delivery of high doses per fraction. Intra-fraction tracking with magnetic resonance imaging-guidance for gated SBRT has shown potential for improved local control. Visualisation of pancreas (and surrounding organs) remains challenging in intra-fraction kilo-voltage (kV) imaging, requiring implanted fiducials. In this study, we investigate patient-specific deep-learning approaches to track the gross-tumour-volume (GTV), pancreas-head and the whole-pancreas in intra-fraction kV images.

Authors

  • Abdella M Ahmed
    Northern Sydney Cancer Centre, Royal North Shore Hospital, St Leonards, NSW, Australia.
  • Levi Madden
    Centre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW 2522, Australia.
  • Maegan Stewart
    Northern Sydney Cancer Centre, Royal North Shore Hospital, Reserve Rd, St Leonards, NSW 2065, Australia.
  • Brian V Y Chow
    Neuroscience Research Australia (NeuRA), Sydney, Australia.
  • Adam Mylonas
    Faculty of Medicine and Health, ACRF Image X Institute, The University of Sydney, Sydney, NSW, Australia.
  • Ryan Brown
    Northern Sydney Cancer Centre, Royal North Shore Hospital, St Leonards, NSW, Australia.
  • Gabrielle Metz
    Northern Sydney Cancer Centre, Royal North Shore Hospital, Reserve Rd, St Leonards, NSW 2065, Australia.
  • Meegan Shepherd
    Department of Radiation Oncology, Northern Sydney Cancer Centre, Royal North Shore Hospital, Reserve Road, St Leonards, NSW, Australia.
  • Carlito Coronel
    Northern Sydney Cancer Centre, Royal North Shore Hospital, Reserve Rd, St Leonards, NSW 2065, Australia.
  • Leigh Ambrose
    Northern Sydney Cancer Centre, Royal North Shore Hospital, Reserve Rd, St Leonards, NSW 2065, Australia.
  • Alex Turk
    Northern Sydney Cancer Centre, Royal North Shore Hospital, Reserve Rd, St Leonards, NSW 2065, Australia.
  • Maiko Crispin
    Northern Sydney Cancer Centre, Royal North Shore Hospital, Reserve Rd, St Leonards, NSW 2065, Australia.
  • Andrew Kneebone
    Department of Radiation Oncology, Northern Sydney Cancer Centre, Royal North Shore Hospital, Reserve Road, St Leonards, NSW, Australia.
  • George Hruby
    Department of Radiation Oncology, Northern Sydney Cancer Centre, Royal North Shore Hospital, Reserve Road, St Leonards, NSW, Australia.
  • Paul Keall
    Radiation Physics Laboratory, University of Sydney, Australia. Electronic address: paul.keall@sydney.edu.au.
  • Jeremy T Booth
    Royal North Shore Hospital, Northern Sydney Cancer Centre, St Leonards, NSW, Australia.

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