Autophagy-related biomarkers in non-obstructive azoospermia: insights from transcriptomics and single-cell sequencing.

Journal: Journal of assisted reproduction and genetics
Published Date: Jun 30, 2025

Abstract

OBJECTIVE: Autophagy, by modulating cellular degradation and recycling processes, affects sperm cell survival and differentiation and may be linked to the pathophysiology of non-obstructive azoospermia (NOA). However, the role of autophagy-related genes (ARGs) in NOA has not yet been fully explored.

Authors

  • Juncheng Yao
    Department of Assisted Reproduction Center, Sichuan Provincial People's Hospital, Chengdu, Sichuan, 610041, China.
  • Yuanyuan Zhang
    National Clinical Research Center for Kidney Disease, State Key Laboratory for Organ Failure Research, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China.
  • Tingting Lan
    Department of Assisted Reproduction Center, Sichuan Provincial People's Hospital, Chengdu, Sichuan, 610041, China. zenghao5640@126.com.
  • Yutao Li
    School of Computer and Communication Engineering, Changsha University of Science and Technology, Changsha 410114, China.

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