Thoracic staging of lung cancers by FDG-PET/CT: impact of artificial intelligence on the detection of associated pulmonary nodules.
Journal:
Physical and engineering sciences in medicine
Published Date:
Jun 30, 2025
Abstract
This study focuses on automating the classification of certain thoracic lung cancer stages in 3D FDG-PET/CT images according to the 9th Edition of the TNM Classification for Lung Cancer (2024). By leveraging advanced segmentation and classification techniques, we aim to enhance the accuracy of distinguishing between T4 (pulmonary nodules) Thoracic M0 and M1a (pulmonary nodules) stages. Precise segmentation of pulmonary lobes using the Pulmonary Toolkit enables the identification of tumor locations and additional malignant nodules, ensuring reliable differentiation between ipsilateral and contralateral spread. A modified ResNet-50 model is employed to classify the segmented regions. The performance evaluation shows that the model achieves high accuracy. The unchanged class has the best recall 93% and an excellent F1 score 91%. The M1a (pulmonary nodules) class performs well with an F1 score of 94%, though recall is slightly lower 91%. For T4 (pulmonary nodules) Thoracic M0, the model shows balanced performance with an F1 score of 87%. The overall accuracy is 87%, indicating a robust classification model.
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