Activation of LAMP1-mediated lipophagy by sulforaphane inhibits cellular senescence and intervertebral disc degeneration.

Journal: Journal of orthopaedic translation
Published Date: Jun 2, 2025

Abstract

BACKGROUND: Intervertebral disc degeneration (IDD) is a major cause of chronic low back pain, involving lipid dysregulation and cellular senescence in nucleus pulposus (NP) cells. However, the relationship between lipid accumulation and cellular senescence in IDD remain unclear. This study aims to investigate whether lipid accumulation promotes NP cell senescence and explore the role of LAMP1-mediated lipophagy in mitigating these effects.

Authors

  • Tianyu Qin
    Division of Spine, Department of Orthopedic Surgery, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, Shenzhen, 518020, Guangdong, China.
  • Ming Shi
    Faculty of Computing and Meta-Technology, Universiti Pendidikan Sultan Idris, Tanjong Malim, Perak, Malaysia.
  • Yongheng Xie
    Division of Spine, Department of Orthopedic Surgery, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, Shenzhen, 518020, Guangdong, China.
  • Naibo Feng
    Division of Spine, Department of Orthopedic Surgery, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, Shenzhen, 518020, Guangdong, China.
  • Chungeng Liu
    Division of Spine, Department of Orthopedic Surgery, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, Shenzhen, 518020, Guangdong, China.
  • Ke Chen
    Department of Signal Processing, Tampere University of Technology, Finland.
  • Yining Chen
    Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.
  • Wanli Zheng
    Jinzhou Medical University, Jinzhou, China.
  • Mingxi Zhu
    Department of Orthopedics, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, 528406, Guangdong, China.
  • Songlin Peng
    Division of Spine, Department of Orthopedic Surgery, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, Shenzhen, 518020, Guangdong, China.
  • Guozhi Xiao
    Shenzhen Key Laboratory of Musculoskeletal Tissue Reconstruction and Function Restoration, Shenzhen, 518020, Guangdong, China.
  • Houqing Long
    Division of Spine, Department of Orthopedic Surgery, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, Shenzhen, 518020, Guangdong, China.

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