Multisensory BCI promotes motor recovery via high-order network-mediated interhemispheric integration in chronic stroke.

Journal: BMC medicine
Published Date: Jul 1, 2025

Abstract

BACKGROUND: Chronic stroke patients often experience persistent motor impairments, and current rehabilitation therapies rarely achieve substantial functional recovery. Sensory feedback during movement plays a pivotal role in driving neuroplasticity. This study introduces a novel multi-modal sensory feedback brain-computer interface (Multi-FDBK-BCI) system that integrates proprioceptive, tactile, and visual stimuli into motor imagery-based training. We aimed to explore the potential therapeutic efficacy and elucidate its neural mechanisms underlying motor recovery.

Authors

  • Rongrong Lu
    Department of Rehabilitation, Huashan Hospital, Fudan University, No. 12 Middle Wulumuqi Road, Shanghai, 200040, China.
  • Zhen Pang
    Department of Rehabilitation, Huashan Hospital, Fudan University, No. 12 Middle Wulumuqi Road, Shanghai, 200040, China.
  • Tianhao Gao
    Department of Rehabilitation, Huashan Hospital, Fudan University, No. 12 Middle Wulumuqi Road, Shanghai, 200040, China.
  • Zhijie He
    Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, China.
  • Yiqian Hu
    Department of Rehabilitation, Shanghai Geriatric Medical Center, No. 2560 Chunshen Road, Shanghai, 200237, China.
  • Jie Zhuang
    School of Psychology, Shanghai University of Sport, Shanghai, China.
  • Qin Zhang
    Department of Burn, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Zhengrun Gao
    Department of Neurology, Songjiang Research Institute, Shanghai Key Laboratory of Emotions and Affective Disorders, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China. zrgao@shsmu.edu.cn.

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