Atrophy related neuroimaging biomarkers for neurological and cognitive function in Wilson disease.

Journal: Neurological research and practice
Published Date: Jul 1, 2025

Abstract

BACKGROUND: Although brain atrophy is a prevalent finding in Wilson disease (WD), its role as a contributing factor to clinical symptoms, especially cognitive decline, remains unclear. The objective of this study was to investigate different neuroimaging biomarkers related to grey matter atrophy and their relationship with neurological and cognitive impairment in WD.

Authors

  • Ann Carolin Hausmann
    Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
  • Christian Rubbert
    Department of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, 40225, Dusseldorf, Germany. christian.rubbert@med.uni-duesseldorf.de.
  • Silja K Querbach
    Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
  • Vivien Lorena Ivan
    Department of Diagnostic and Interventional Radiology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Germany.
  • Alfons Schnitzler
    Department of Neurology, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
  • Christian Johannes Hartmann
    Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany. Christian.Hartmann@med.uni-duesseldorf.de.
  • Julian Caspers
    Department of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, 40225, Dusseldorf, Germany.

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