MRI radiomics model for predicting tumor immune microenvironment types and efficacy of anti-PD-1/PD-L1 therapy in hepatocellular carcinoma.

Journal: BMC medical imaging
Published Date: Jul 1, 2025

Abstract

BACKGROUND: To improve the prediction of immune checkpoint inhibitors (ICIs) efficacy in hepatocellular carcinoma (HCC), this study categorized the tumor immune microenvironment (TIME) into two types: immune-activated (IA), characterized by a high CD8 + score and high PD-L1 combined positive score (CPS), and non-immune-activated (NIA), encompassing all other conditions. We aimed to develop an MRI-based radiomics model to predict TIME types and validate its predictive capability for ICIs efficacy in HCC patients receiving anti-PD-1/PD-L1 therapy.

Authors

  • Rui Zhang
    Department of Cardiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, China.
  • Wei Peng
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, United States.
  • Yao Wang
    Department of Gastrointestinal Surgery, Zhongshan People's Hospital, Zhongshan, Guangdong, China.
  • Yunping Jiang
    Department of Radiology, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou, 310003, China.
  • Junli Wang
    Key Laboratory of Embedded System and Service Computing (Tongji University), Ministry of Education, Shanghai 201804, China.
  • Siying Zhang
    Department of Radiology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
  • Zhi Li
    Department of Nursing, Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine, Zhongshan, China.
  • Yushu Shi
    Department of Radiology, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou, 310003, China.
  • Feng Chen
    Department of Integrated Care Management Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Zhan Feng
    Department of Radiology, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou, 310003, China.
  • Wenbo Xiao
    Department of Neurology, School of Medicine, The Fourth Affiliated Hospital of Zhejiang University, Yiwu, China.

Keywords

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