Chimeric mis-annotations of genes remain pervasive in eukaryotic non-model organisms.
Journal:
BMC genomics
Published Date:
Jul 1, 2025
Abstract
BACKGROUND: Accurate annotation of protein-coding genes is critical for genome analysis in non-model organisms. However, limited RNA-Seq data and incomplete protein resources can lead to errors, including chimeric gene mis-annotations, where two or more adjacent genes are incorrectly fused into a single model. These errors often persist due to annotation inertia, where mistakes are propagated and amplified through data sharing and reanalysis, and leads to cases where the mis-annotated model becomes favoured over the correct model. This complicates almost all downstream genomic analyses such as gene expression studies and comparative genomics.
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