Cocaine-Induced Apoplexy of a GH-Secreting Pituitary Tumor.

Journal: Clinical case reports
Published Date: May 12, 2025

Abstract

A 25-year-old previously healthy man presents to the clinic with a severe headache after cocaine consumption. Physical examination revealed acromegaloid features, and the hormonal profile revealed an IGF-1 of 308 ng/mL (40.8 nmol/L) (normal reference range 197-333 ng/mL; 17.8-45.6). An MRI showed a heterogeneous, cystic lesion of the pituitary gland with hematic contents, consistent with the diagnosis of a pituitary apoplexy. Considering the normal IGF-1 level, the patient was classified to be in remission, which deems it unnecessary to initiate pharmacologic or surgical treatment. Remission of acromegaly after a pituitary apoplexy is an extremely rare event, and pituitary apoplexy after cocaine consumption is also anecdotal. We present the first case of remission of acromegaly after a cocaine-induced pituitary apoplexy.

Authors

  • Dalia Cuenca
    Department of Medicine American British Cowdray Medical Center Mexico City Mexico.
  • Latife Salame-Khouri
    Department of Neurology Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Mexico City Mexico.
  • Daniela Shveid-Gerson
    Department of Medicine American British Cowdray Medical Center Mexico City Mexico.
  • Marco Antonio Alegría-Loyola
    Department of Medicine American British Cowdray Medical Center Mexico City Mexico.
  • Moises Mercado
    Endocrine Research Unit, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, IMSS Mexico City Mexico.

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