Metabolic profiles and prediction of failure to thrive of citrin deficiency with normal liver function based on metabolomics and machine learning.

Journal: Nutrition & metabolism
Published Date: May 12, 2025

Abstract

PURPOSE: This study aimed to explore metabolite pathways and identify residual metabolites during the post-neonatal intrahepatic cholestasis caused by citrin deficiency (post-NICCD) phase, while developing a predictive model for failure to thrive (FTT) using selected metabolites.

Authors

  • Peiyao Wang
    Department of Genetics and Metabolism, Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, No. 3333 Binsheng Road, Binjiang District, Hangzhou City, Zhejiang Province, 310052, China.
  • Duo Zhou
    Department of Genetics and Metabolism, Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, No. 3333 Binsheng Road, Binjiang District, Hangzhou City, Zhejiang Province, 310052, China.
  • Lingwei Hu
    Department of Genetics and Metabolism, Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, No. 3333 Binsheng Road, Binjiang District, Hangzhou City, Zhejiang Province, 310052, China.
  • Pingping Ge
    Department of Genetics and Metabolism, Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, No. 3333 Binsheng Road, Binjiang District, Hangzhou City, Zhejiang Province, 310052, China.
  • Ziyan Cen
    Department of Genetics and Metabolism, Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, No. 3333 Binsheng Road, Binjiang District, Hangzhou City, Zhejiang Province, 310052, China.
  • Zhenzhen Hu
    Department of Genetics and Metabolism, Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, No. 3333 Binsheng Road, Binjiang District, Hangzhou City, Zhejiang Province, 310052, China.
  • Qimin He
    School of Geography Science and Geomatics Engineering, Suzhou University of Science and Technology, Suzhou, 215009, China. heqimin@usts.edu.cn.
  • Kejun Zhou
    Human Metabolomics Institute, Inc., Shenzhen, Guangdong, 518109, China. zhoukejun1984@163.com.
  • Benqing Wu
    Children's Medical Center, Shenzhen Guangming District People's Hospital, Shenzhen, Guangdong, 518106, China. wubenqing783@126.com.
  • Xinwen Huang
    Department of Genetics and Metabolism, Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, No. 3333 Binsheng Road, Binjiang District, Hangzhou City, Zhejiang Province, 310052, China. 6305022@zju.edu.cn.

Keywords

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