F-FDG dose reduction using deep learning-based PET reconstruction.

Journal: EJNMMI research
Published Date: Jul 1, 2025

Abstract

BACKGROUND: A deep learning-based image reconstruction (DLR) algorithm that can reduce the statistical noise has been developed for PET/CT imaging. It may reduce the administered dose of F-FDG and minimize radiation exposure while maintaining diagnostic quality. This retrospective study evaluated whether the injected F-FDG dose could be reduced by applying DLR to PET images. To this aim, we compared the quantitative image quality metrics and the false-positive rate between DLR with a reduced F-FDG dose and Ordered Subsets Expectation Maximization (OSEM) with a standard dose.

Authors

  • Ryuji Akita
    Department of Diagnostic Radiology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan. akita13@hiroshima-u.ac.jp.
  • Komei Takauchi
    Department of Radiology, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
  • Mana Ishibashi
    Center for Radiation Disaster Medical Science, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
  • Shota Kondo
    Diagnostic Radiology, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
  • Shogo Ono
    CT Systems Development Department, Canon Medical Systems Corporation, 1385 Shimoishigami, Otawara City, Tochigi, 324-8550, Japan.
  • Kazushi Yokomachi
    Department of Radiology, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
  • Yusuke Ochi
    Department of Radiology, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
  • Masao Kiguchi
    Department of Radiology, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
  • Hidenori Mitani
    Diagnostic Radiology, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
  • Yuko Nakamura
    Department of Diagnostic Radiology, Graduate School of Biomedical and Health Science, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
  • Kazuo Awai
    Department of Diagnostic Radiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.

Keywords

No keywords available for this article.

External Resources

Popular Topics
Recent Journals