Machine learning based obesity and aging related signature for predicting the prognosis and immunotherapy benefit in stomach adenocarcinoma.

Journal: Discover oncology
Published Date: Jul 1, 2025

Abstract

BACKGROUND: Stomach adenocarcinoma (STAD) is one of most common cancers with high invasiveness and poor prognosis. Obesity and aging are correlated with higher risk for cancer development and worse prognosis in certain types of malignancies.

Authors

  • Yongheng Chen
    Department of Oncology, NHC Key Laboratory of Cancer Proteomics, Xiangya Hospital, Central South University, Xiangya Road, Changsha, 410008, China. yonghenc@163.com.
  • Xiaoxia Yu
    Department of Hospice, the First Affiliated Hospital of Shantou University Medical College, Shantou, China.
  • Wencan Xu
    Department of Endocrinology and Metabolism, the First Affiliated Hospital of Shantou University Medical College, Shantou, China.
  • Anqi Huang
    Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Ministry of Education); Wuhan University School of Pharmaceutical Sciences, Wuhan, 430071, China.
  • Zhengbing Li
    Department of Endocrinology and Metabolism, the First Affiliated Hospital of Shantou University Medical College, Shantou, China. lzbing2022@163.com.

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