A manganese metabolism-related gene signature stratifies prognosis and immunotherapy efficacy in kidney cancer.

Journal: Discover oncology
Published Date: Jul 1, 2025

Abstract

BACKGROUND: Manganese modulates tumorigenesis and immune regulation. High levels of manganese may promote cancer progression. While manganese toxicity causes renal tubular damage and chronic impairment, its association with kidney cancer remains poorly understood.

Authors

  • Yang Liu
    Department of Computer Science, Hong Kong Baptist University, Hong Kong, China.
  • Hao Ye
    Department of Urology, Tianjin Medical University General Hospital, No 154. Anshan Road, Tianjin, 300052, China.
  • Ruoxuan Zhang
    Department of Urology, Tianjin Medical University General Hospital, No 154. Anshan Road, Tianjin, 300052, China.
  • Xiaolong Liu
    The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, People's Republic of China.
  • Ranlu Liu

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