Rhaponticin inhibits the proliferation, migration, and invasion of head and neck squamous cell carcinoma (HNSCC) cells through modulation of the IL6/STAT3 signaling pathway.

Journal: Discover oncology
Published Date: Jul 1, 2025

Abstract

BACKGROUND: Rhaponticin, a bioactive compound derived from rhubarb, has been demonstrated anti-tumor effects in various types of cancer. However, its impact on HNSCC remains unexplored. This study aims to investigate the specific molecular mechanisms by which Rhaponticin inhibits the invasion and metastasis of HNSCC cells.

Authors

  • Hongcheng Wei
    Department of Oral and Maxillofacial Surgery, Key Laboratory of Oral Diseases of Traditional Chinese Medicine, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, 445 Bayi Dadao, Nanchang, 360000, Jiangxi, China.
  • Shanshan Wang
    Key Laboratory of Agri-food Safety and Quality, Institute of Quality Standard and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Ministry of Agriculture of China, Beijing, 100081, PR China.
  • Jiayue Wan
    Graduate School of Jiangxi, University of Traditional Chinese Medicine, Nanchang, 330004, Jiangxi, China.
  • Sicheng Li
    Department of Oral and Maxillofacial Surgery, Key Laboratory of Oral Diseases of Traditional Chinese Medicine, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, 445 Bayi Dadao, Nanchang, 360000, Jiangxi, China.
  • Wei Wang
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China.
  • Jiajun Zhu
    Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou 310000, China.
  • Lin Jiang
    State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
  • Yisen Shao
    Department of Oral and Maxillofacial Surgery, Key Laboratory of Oral Diseases of Traditional Chinese Medicine, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, 445 Bayi Dadao, Nanchang, 360000, Jiangxi, China. shaoyisen@jxutcm.edu.cn.
  • Yuan Wu
    State Key Laboratory of Precision Spectroscopy, Quantum Institute for Light and Atoms, Department of Physics and Electronic Science, East China Normal University, Shanghai 200062, China.

Keywords

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