Discovery of novel cathepsin K inhibitors for osteoporosis treatment using a deep learning-based strategy.
Journal:
Expert opinion on drug discovery
Published Date:
Jul 2, 2025
Abstract
BACKGROUND: Cathepsin K (CTSK), a cysteine protease of the papain family, exhibits high expression in activated osteoclasts, making it a key therapeutic target for osteoporosis. However, there are currently no CTSK inhibitors available for clinical use.
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