Novel technologies for REM sleep behavior disorder detection for home screening in Parkinson's disease and related alpha-synucleinopathies.

Journal: NPJ Parkinson's disease
Published Date: Jul 3, 2025

Abstract

Isolated REM sleep behavior disorder (iRBD) is a prodromal marker of Parkinson's disease (PD) and related alpha-synucleinopathies. Identification of RBD is crucial for timely intervention and disease-modifying treatments. While video-polysomnography (vPSG) remains the diagnostic gold standard, its costly and resource-intensive nature limits its utility. This systematic review evaluates emerging non-PSG tools and modalities for home-based RBD detection. A systematic search of PubMed, Web of Science, and Cochrane Library identified 17 studies, categorized into actigraphy devices (n = 9), novel tools (n = 5), and emerging modalities (n = 3). Advances in actigraphy, through machine learning integration, have significantly improved RBD detection. Novel tools, including portable biopotential systems and temporary tattoo electrodes, show promise for home-based REM sleep without atonia monitoring, while contactless cameras demonstrate high sensitivity for dream-enacting behavior detection. Future studies for validation are needed, ensuring reliability and clinical applicability for large-scale screening efforts aimed at identifying individuals at risk for PD and related alpha-synucleinopathies.

Authors

  • Kaat Colman
    Department of Neurology, Antwerp University Hospital, Antwerp, Belgium. Kaat.colman@uantwerpen.be.
  • An-Marie Schyvens
    Multidisciplinary Sleep Disorders Centre, Antwerp University Hospital, Edegem, Belgium.
  • Ilse De Volder
    Department of Neurology, Antwerp University Hospital, Antwerp, Belgium.
  • Johan Verbraecken
    Multidisciplinary Sleep Disorders Centre, Antwerp University Hospital, Edegem, Belgium.
  • Angelique Pijpers
    Sleep Medicine Centre Kempenhaeghe, Heeze, The Netherlands.
  • Mineke Viaene
    Laboratory of Sleep Disorders, Regional Hospital Geel, Geel, Belgium.
  • Wolfgang Oertel
    Department of Neurology, Philips-University Marburg, Marburg, Germany.
  • Femke Dijkstra
    Department of Neurology, Antwerp University Hospital, Antwerp, Belgium.
  • David Crosiers
    Department of Neurology, Antwerp University Hospital, Antwerp, Belgium.

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