Quantitative CT Imaging in Chronic Obstructive Pulmonary Disease.

Journal: The British journal of radiology
Published Date: Jul 4, 2025

Abstract

Chronic obstructive pulmonary disease (COPD) is a highly heterogeneous condition characterized by diverse pulmonary and extrapulmonary manifestations. Efforts to quantify its various components using CT imaging have advanced, aiming for more precise, objective, and reproducible assessment and management. Beyond emphysema and small airway disease, the two major components of COPD, CT quantification enables the evaluation of pulmonary vascular alteration, ventilation-perfusion mismatches, fissure completeness, and extrapulmonary features such as altered body composition, osteoporosis, and atherosclerosis. Recent advancements, including the application of deep learning techniques, have facilitated fully automated segmentation and quantification of CT parameters, while innovations such as image standardization hold promise for enhancing clinical applicability. Numerous studies have reported associations between quantitative CT parameters and clinical or physiologic outcomes in patients with COPD. However, barriers remain to the routine implementation of these technologies in clinical practice. This review highlights recent research on COPD quantification, explores advances in technology, and also discusses current challenges and potential solutions for improving quantification methods.

Authors

  • Sohee Park
    Department of Radiology and Research Institute of Radiology, Asan Medical Center, College of Medicine, University of Ulsan, 88 Olympic-ro 43 Gil, Songpa-gu, Seoul, 138736, South Korea.
  • Sang Min Lee
    Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
  • Hye Jeon Hwang
    Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • Sang Young Oh
    From the Department of Radiology and Research Institute of Radiology (J.Y., Y.A., S.Y.O., S.M.L., J.B.S.) and Department of Convergence Medicine (K.C., N.K.), University of Ulsan College of Medicine, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 138-736, Korea.
  • Jooae Choe
    Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
  • Joon Beom Seo
    Department of Radiology, Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, Korea.

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