Development of machine learning prediction models for systemic inflammatory response following controlled exposure to a live attenuated influenza vaccine in healthy adults using multimodal wearable biosensors in Canada: a single-centre, prospective controlled trial.

Journal: The Lancet. Digital health
Published Date:

Abstract

BACKGROUND: Presymptomatic or asymptomatic immune system signals and subclinical physiological changes might provide a more objective measure of early viral upper respiratory tract infections (VRTIs) compared with symptom-based detection. We aimed to use multimodal wearable sensors, host-response biomarkers, and machine learning to predict systemic inflammation following controlled exposure to a live attenuated influenza vaccine, without relying on symptoms.

Authors

  • Amir Hadid
    Clinical Exercise and Respiratory Physiology Laboratory, Department of Kinesiology and Physical Education, Faculty of Education, McGill University, Montréal, QC, Canada; Sylvan Adams Sport Science Institute, Faculty of Education, McGill University, Montréal, QC, Canada. Electronic address: amir.hadid@gmail.com.
  • Emily G McDonald
    Division of General Internal Medicine, Department of Medicine, McGill University Health Center, Montréal, QC, Canada.
  • Qianggang Ding
    Clinical Exercise and Respiratory Physiology Laboratory, Department of Kinesiology and Physical Education, Faculty of Education, McGill University, Montréal, QC, Canada; Mila - Quebec AI Institute, Montréal, QC, Canada.
  • Christopher Phillipp
    Clinical Exercise and Respiratory Physiology Laboratory, Department of Kinesiology and Physical Education, Faculty of Education, McGill University, Montréal, QC, Canada.
  • Audrey Trottier
    Clinical Exercise and Respiratory Physiology Laboratory, Department of Kinesiology and Physical Education, Faculty of Education, McGill University, Montréal, QC, Canada.
  • Philippe C Dixon
    Institute of Biomedical Engineering, Faculty of Medicine, University of Montreal, Canada; Research Center of the Sainte-Justine University Hospital (CRCHUSJ), Canada; School of Kinesiology and Physical Activity Sciences, Faculty of Medicine, University of Montreal, Canada.
  • Oussama Jlassi
    Department of Kinesiology and Physical Activity, McGill University, Montreal, Québec, Canada. Electronic address: oussama.jlassi@mcgill.ca.
  • Matthew P Cheng
    Division of Infectious Disease, McGill University, Montreal, QC, Canada.
  • Jesse Papenburg
    Division of Pediatric Infectious Diseases, Department of Pediatrics, Montreal Children's Hospital, McGill University Health Centre, Montréal, QC, Canada.
  • Michael Libman
    J.D. MacLean Centre for Tropical Diseases, McGill University, Room E05.1830, 1001 Boulevard Décarie, Montréal, Québec H4A 3J1, Canada.
  • Dennis Jensen
    Department of Molecular Neurology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Schwabachanlage 6, 91054, Erlangen, Germany.

Keywords

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