Multichannel deep learning prediction of major pathological response after neoadjuvant immunochemotherapy in lung cancer: a multicenter diagnostic study.

Journal: International journal of surgery (London, England)
Published Date: Jul 2, 2025

Abstract

OBJECTIVES: This study aimed to develop a pretreatment CT-based multichannel predictor integrating deep learning features encoded by Transformer models for preoperative diagnosis of major pathological response (MPR) in non-small cell lung cancer (NSCLC) patients receiving neoadjuvant immunochemotherapy.

Authors

  • Zuhan Geng
    Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China.
  • Kuo Li
    Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (G.Y., K.L., C.Z., Y.L.).
  • Peiyuan Mei
    Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China.
  • Zhenyu Gong
  • Ruiyang Yan
    Center for Biomedical Engineering, School of Information Science and Technology, Fudan University, Shanghai, 200433.
  • Yu Huang
    School of Data Science and Software Engineering, Qingdao University, Qingdao 266021, China.
  • Chi Zhang
    Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Bowen Zhao
    Guangzhou Institute of Technology, Xidian University, Guangzhou, China.
  • Mingqian Lu
    Department of Oncology, Yichang Central People's Hospital (The First Clinical Medical School of China Three Gorges University), Yichang 443000, Hubei Province, China.
  • Ran Yang
    Radiology Department, Chongqing University Three Gorges Hospital, Chongqing 404000, People's Republic of China.
  • Guangyao Wu
    Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Guanchao Ye
    Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Yongde Liao
    Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Keywords

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