Developing a Panel of Shared Susceptibility Genes as Diagnostic Biomarkers for chronic obstructive pulmonary disease and Heart Failure.

Journal: Computers in biology and medicine
Published Date:

Abstract

AIM: Chronic obstructive pulmonary disease (COPD) and heart failure (HF) are closely intertwined comorbidities that present significant clinical challenges due to the poorly understood pathophysiological mechanisms driving their coexistence. In this study, we systematically identified molecular signatures associated with COPD-HF comorbidity through an integrative bioinformatics analysis of multi-omics datasets. Our findings yielded novel diagnostic biomarkers and elucidated the underlying pathophysiological mechanisms.

Authors

  • Hailong Li
    College of Energy, Xiamen University, Xiamen, 361005 People's Republic of China.
  • Cuncun Huang
    Department of Internal Medicine, First School of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, PR China.
  • Rong Su
    Department of Gastroenterology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.
  • Meng Wang
    State Key Laboratory of Urban Water Resource and Environment, School of Environment, Harbin Institute of Technology, Harbin 150001, China.
  • Yanping Ma
    Department of Geriatrics, Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou, 730000, Gansu Province, PR China.
  • Yafeng Wang
    Department of Geriatrics, Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou, 730000, Gansu Province, PR China.
  • Bingge Xu
    Department of Critical Care Medicine, Shenzhen Nanshan District Hospital, Shenzhen, 730000, Gansu Province, PR China.
  • Kai Liu
    College of Marine Sciences, Shanghai Ocean University, Shanghai 201306, China.

Keywords

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