Developing a Panel of Shared Susceptibility Genes as Diagnostic Biomarkers for chronic obstructive pulmonary disease and Heart Failure.
Journal:
Computers in biology and medicine
Published Date:
Jul 4, 2025
Abstract
AIM: Chronic obstructive pulmonary disease (COPD) and heart failure (HF) are closely intertwined comorbidities that present significant clinical challenges due to the poorly understood pathophysiological mechanisms driving their coexistence. In this study, we systematically identified molecular signatures associated with COPD-HF comorbidity through an integrative bioinformatics analysis of multi-omics datasets. Our findings yielded novel diagnostic biomarkers and elucidated the underlying pathophysiological mechanisms.
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