A comprehensive targeted panel of 295 genes: Unveiling key disease initiating and transformative biomarkers in multiple myeloma.

Journal: Computers in biology and medicine
Published Date: Jul 4, 2025

Abstract

BACKGROUND: Multiple myeloma (MM) is a hematological malignancy that progresses from a benign precursor stage known as Monoclonal Gammopathy of Undetermined Significance (MGUS). Distinguishing MM from MGUS at the molecular level by identifying key biomarkers, genomic alterations, and gene interactions is critical for early detection and deeper insight into MM pathogenesis.

Authors

  • Vivek Ruhela
    SBILab, Deptt. of ECE & Centre of Excellence in Healthcare, Indraprastha Institute of Information Technology Delhi (IIIT-Delhi), India; Department of Computational Biology, Indraprastha Institute of Information Technology Delhi (IIIT-Delhi), India.
  • Ritu Gupta
    Laboratory Oncology Unit, Dr. B.R.A.IRCH, AIIMS, New Delhi 110029, India. Electronic address: drritugupta@gmail.com.
  • Rupin Oberoi
    SBILab, Deptt. of ECE & Centre of Excellence in Healthcare, Indraprastha Institute of Information Technology Delhi (IIIT-Delhi), India.
  • Anubha Gupta
    SBILab, Deptt. of ECE, IIIT-Delhi, Delhi, India.

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