Evaluating the Performance and Potential Bias of Predictive Models for Detection of Transthyretin Cardiac Amyloidosis.

Journal: JACC. Advances
Published Date:

Abstract

BACKGROUND: Delays in the diagnosis of transthyretin amyloid cardiomyopathy (ATTR-CM) contribute to the significant morbidity of the condition, especially in the era of disease-modifying therapies. Screening for ATTR-CM with artificial intelligence and other algorithms may improve timely diagnosis, but these algorithms have not been directly compared.

Authors

  • Jonathan Hourmozdi
    Northwestern University, Feinberg School of Medicine, Chicago, IL.
  • Nicholas Easton
    Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA; Bluhm Cardiovascular Institute Center for AI, Northwestern Medicine, Chicago, Illinois, USA.
  • Simon Benigeri
    Division of Cardiology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
  • James D Thomas
    Bluhm Cardiovascular Institute, Department of Cardiology, Northwestern University, Chicago, Illinois. Electronic address: Jthomas8@nm.org.
  • Akhil Narang
    Cardiac Imaging Center, University of Chicago Medical Center, Chicago, Illinois.
  • David Ouyang
    Division of Artificial Intelligence, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Grant Duffy
    Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, 127 S San Vicente Blvd A3600, Los Angeles, CA 90048, United States.
  • Ross Upton
    Ultromics Ltd, Oxford, United Kingdom.
  • Will Hawkes
    Ultromics Limited, Oxford, United Kingdom.
  • Ashley Akerman
    Ultromics Limited, Oxford, United Kingdom.
  • Ike Okwuosa
    Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  • Adrienne Kline
  • Abel N Kho
    Northwestern University, Evanston, IL.
  • Yuan Luo
    Department of Preventive Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
  • Sanjiv J Shah
    Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
  • Faraz S Ahmad
    Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

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