Radiographic Bone Texture Analysis using Deep Learning Models for Early Rheumatoid Arthritis Diagnosis.

Journal: Journal of imaging informatics in medicine
Published Date: Jul 7, 2025

Abstract

Rheumatoid arthritis (RA) is distinguished by the presence of modified bone microarchitecture, also known as 'texture,' in the periarticular regions. The radiographic detection of such alterations in RA can be challenging. To train and to validate a deep learning model to quantitatively produce periarticular texture features directly from radiography and predict the diagnosis of early RA without human reading. Two kinds of deep learning models were compared for diagnostic performance. Anterior-posterior bilateral hands radiographs of 891 early RA (within one year of initial diagnosis) and 1237 non-RA patients were split into a training set (64%), a validation set (16%), and a test set (20%). The second, third, and fourth distal metacarpal areas were segmented for the Deep Texture Encoding Network (Deep-TEN; texture-based) and residual network-50 (ResNet-50; texture and structure-based) models to predict the probability of RA. The area under the curve of the receiver operating characteristics curve for RA was 0.69 for the Deep-TEN model and 0.73 for the ResNet-50 model. The positive predictive values of a high texture score to classify RA using the Deep-TEN and ResNet-50 models were 0.64 and 0.67, respectively. High mean texture scores were associated with age- and sex-adjusted odds ratios (ORs) with 95% confidence interval (CI) for RA of 3.42 (2.59-4.50) and 4.30 (3.26-5.69) using the Deep-TEN and ResNet-50 models, respectively. The moderate and high RA risk groups determined by the Deep-TEN model were associated with adjusted ORs (95% CIs) of 2.48 (1.78-3.47) and 4.39 (3.11-6.20) for RA, respectively, and those using the ResNet-50 model were 2.17 (1.55-3.04) and 6.91 (4.83-9.90), respectively. Fully automated quantitative assessment for periarticular texture by deep learning models can help in the classification of early RA.

Authors

  • Yun-Ju Huang
    Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, No.5, Fuxing St., Guishan District, Taoyuan, 333, Taiwan.
  • Chiung-Hung Lin
    Division of Pulmonology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
  • Shun Miao
    Siemens Healthineers, Medical Imaging Technologies, Princeton, NJ, USA.
  • Kang Zheng
    PAII Inc., Bethesda, MD, USA.
  • Le Lu
  • Yuhang Lu
    School of Public Health, Chengdu Medical College, Chengdu 610500, China.
  • Chihung Lin
    Center for Artificial Intelligence in Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan.
  • Chang-Fu Kuo
    Department of Rheumatology, Allergy, and Immunology, Chang Gung Memorial Hospital, Taipei, Taiwan, ROC.

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