Multi-omics analysis of the effects of pla2g4a on the prognosis of various cancers and its experimental validation in breast cancer cell lines.

Journal: Discover oncology
Published Date: Jul 7, 2025

Abstract

BACKGROUND: Platelet-related exosomes (PREs) are microparticles secreted by platelets into the bloodstream and are implicated in various cancer processes. This study aims to identify critical genes involved in Breast Cancer (BC)-associated PREs and to evaluate their role in cancer prognosis. PLA2G4A was identified as a key gene through the use of machine learning techniques and various genomic analyses, providing a foundation for precision medicine in BC treatment.

Authors

  • Yao Qian
    Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, 150000, Heilongjiang, China.
  • Quan Yuan
    School of Vehicle and Mobility, Tsinghua University, Beijing 100084, China.
  • Hao Yu
    Shanghai Key Lab of Trustworthy Computing, East China Normal University, Shanghai, China.
  • Rongjie Ye
    Department of Orthopaedics, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, China.
  • Ming Niu
    Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, 150000, Heilongjiang, China. niuming2024@126.com.
  • Feng Liu
    Department of Vascular and Endovascular Surgery, The First Medical Center of Chinese PLA General Hospital, 100853 Beijing, China.

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