Construction of a novel CD8T cell-related index for predicting clinical outcomes and immune landscape in ovarian cancer by combined single-cell and RNA-sequencing analysis.

Journal: Discover oncology
Published Date: May 12, 2025

Abstract

BACKGROUND: CD8T cells, also known as cytotoxic T lymphocytes, play a key role in the tumor immune microenvironment (TME) and immune response. The aim of this study was to explore the potential role of CD8T cell-associated biomarkers in predicting prognosis and immunotherapy efficacy in ovarian cancer.

Authors

  • Yu Zhang
    College of Marine Electrical Engineering, Dalian Maritime University, Dalian, China.
  • Peng Wan
    Department of Chemoradiotherapy, The Affiliated People's Hospital of Ningbo University, Ningbo, China.
  • Liangliang Wang
    Department of Chemoradiotherapy, The Affiliated People's Hospital of Ningbo University, Ningbo, China.
  • Ruiping Ren
    Department of Chemoradiotherapy, The Affiliated People's Hospital of Ningbo University, Ningbo, China.

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