Validation of the Toronto recurrence inference using machine-learning for post-transplant hepatocellular carcinoma model.

Journal: Communications medicine
Published Date: Jul 9, 2025

Abstract

BACKGROUND: Organ shortages require prioritizing hepatocellular carcinoma (HCC) patients with the highest survival benefit for allografts. While traditional models like AFP, MORAL, and HALT-HCC are commonly used for recurrence risk prediction, the TRIUMPH model, which uses machine learning, has shown superior performance. This study aims to externally validate the model.

Authors

  • Zhihao Li
    Heilongjiang University of CM, Harbin 150040, China.
  • Itsuko Chih-Yi Chen
    Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
  • Leonardo Centonze
    Department of General Surgery and Transplantation, Niguarda Ca' Granda Hospital, Milan, Italy.
  • Christian T J Magyar
    HBP & Multi-Organ Transplant Program, University Health Network, Toronto, Canada.
  • Woo Jin Choi
    HBP & Multi-Organ Transplant Program, University Health Network, Toronto, Canada.
  • Tommy Ivanics
    Multi-Organ Transplant Program, University Health Network.
  • Grainne M O'Kane
    Department of Medical Oncology, St. Vincent's University Hospital, Dublin, Republic of Ireland.
  • Arndt Vogel
    Klinik für Gastroenterologie, Hepatologie, Infektiologie und Endokrinologie, Medizinische Hochschule Hannover, Hannover, Deutschland.
  • Lauren Erdman
    Genetics and Genome Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Luciano De Carlis
    Department of General Surgery and Abdominal Transplantation, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
  • Jan Lerut
    Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, 10 Avenue Hippocrate, 1200, Brussels, Belgium.
  • Quirino Lai
    General Surgery and Organ Transplantation Unit, Sapienza University of Rome, Rome, Italy.
  • Vatche G Agopian
    Department of Surgery, Dumont-UCLA Transplant and Liver Cancer Centers, University of California at Los Angeles, Los Angeles, California, United States.
  • Neil Mehta
    Cleveland Clinic, USA.
  • Chao-Long Chen
    Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
  • Gonzalo Sapisochin
    Multi-Organ Transplant Program, University Health Network.

Keywords

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