Mechanobiology-guided machine learning models for predicting long bone fracture healing across diverse scenarios.

Journal: Computers in biology and medicine
Published Date: Jul 7, 2025

Abstract

BACKGROUND: Fracture healing is a complex, time-dependent process governed by biological and mechanical factors, including implant properties. While finite element (FE) modeling provides detailed mechanobiological insights into this process, its computational cost remains a major limitation for widespread clinical or research use. In this study, we developed and validated a machine learning (ML) framework as a rapid alternative for a previously validated 21-day mechanoregulation-based FE model of femoral fracture healing in rodents.

Authors

  • Ahmad Hedayatzadeh Razavi
    Musculoskeletal Translational Innovation Initiative, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Department of Mechanical Engineering, Boston University, Boston, MA, USA.
  • Mohammad Hemmati
    College of Science and Mathematics, University of Massachusetts Boston, Boston, MA, USA.
  • Nazanin Nafisi
    Musculoskeletal Translational Innovation Initiative, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Department of Mechanical Engineering, Boston University, Boston, MA, USA.
  • Alireza Mirahmadi
    Musculoskeletal Translational Innovation Initiative, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Shubham Laiwala
    Musculoskeletal Translational Innovation Initiative, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Mario Keko
    Carl J. Shapiro, Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Ashkan Vaziri
    BioSensics, LLC, Newton, MA, USA.
  • Edward K Rodriguez
    Carl J. Shapiro Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center (BIDMC) and Harvard Medical School, 330 Brookline Avenue, Stoneman 10, Boston, MA, 02215, USA.
  • Ara Nazarian
    Carl J. Shapiro Department of Orthopaedic Surgery Musculoskeletal Translational Innovation Initiative, Beth Israel Deaconess Medical Center, Harvard Medical School Boston Massachusetts USA.

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