Electrophysiological-based automatic subgroups diagnosis of patients with chronic dysimmune polyneuropathies.

Journal: Journal of neuroengineering and rehabilitation
Published Date: Jul 7, 2025

Abstract

BACKGROUND: Chronic Dysimmune Polyneuropathies (CDP) encompass a group of conditions characterized by autoimmune etiology targeting myelin and/or axonal components. Subgroups include Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) and paraproteinemic neuropathies associated with IgM monoclonal gammopathy of undetermined significance, with anti-MAG antibodies (IgM-MGUS anti-MAG+) and without anti-MAG antibodies (IgM-MGUS anti-MAG-). Their identification is crucial for determining the most suitable treatment options, yet it poses significant challenges. In this study, an electrophysiological-based automatic classification through machine learning models is proposed.

Authors

  • Sara Ballanti
    The Biorobotics Institute, Scuola Superiore Sant'Anna, Pontedera, Pisa, 56025, Italy.
  • Piergiuseppe Liuzzi
    Scuola Superiore Sant'Anna, The BioRobotics Institute, Viale Rinaldo Piaggio 34, 56025, Pontedera, PI, Italy.
  • Paolo Luca Mattiolo
    Neurophysiology Unit, AOU Careggi, Florence, 50143, Italy.
  • Maenia Scarpino
    Neurophysiology Unit, AOU Careggi, Florence, 50143, Italy.
  • Sabrina Matà
    Neurology Unit, AOU Careggi, Florence, 50143, Italy.
  • Bahia Hakiki
    IRCCS Fondazione Don Carlo Gnocchi onlus, Via di Scandicci 269, Firenze, 50143, Italy.
  • Francesca Cecchi
    IRCCS Fondazione Don Carlo Gnocchi onlus, Via di Scandicci 269, Firenze, 50143, Italy.
  • Calogero Maria Oddo
    Sant'Anna School of Advanced Studies, The BioRobotics Institute, 56025 Pisa, Italy. calogero.oddo@santannapisa.it.
  • Andrea Mannini
    IRCCS Fondazione Don Carlo Gnocchi onlus, Via di Scandicci 269, Firenze, 50143, Italy. amannini@dongnocchi.it.
  • Antonello Grippo
    IRCCS Fondazione Don Carlo Gnocchi onlus, Via di Scandicci 269, Firenze, 50143, Italy.

Keywords

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