Identification of a novel ferroptosis-induced immunogenic cell death related signature based on a machine learning framework in colorectal cancer.

Journal: Discover oncology
Published Date: Jul 9, 2025

Abstract

BACKGROUND: Ferroptosis and immunogenic cell death play vital roles in colorectal cancer (CRC). The interplay between ferroptosis and immunogenic cell death (F-ICD) represents a promising frontier in cancer therapy. However, few studies have explored the combined regulatory effects of F-ICD in CRC.

Authors

  • Feng Zhu
    Department of Critical Care Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, People's Republic of China.
  • Xin Liu
    Peking University Institute of Advanced Agricultural Sciences, Shandong Laboratory of Advanced Agricultural Sciences, Weifang, Shandong, China.
  • Huiyuan Li
    School of Electrical Engineering, Yancheng Institute of Technology, Yancheng 224051, PR China. Electronic address: lihuiyuan518@163.com.
  • Jianfeng Li
    Beijing Key Laboratory of Advanced Manufacturing Technology, Faculty of Materials and Manufacturing, Beijing University of Technology, No. 100 Pingleiyuan, Chaoyang District, Beijing, China.
  • Hongzhang Liu
    School of Materials Science and Engineering, China University of Petroleum (East China), Qingdao 266580, Shandong, China.
  • Yusheng Wang
    General Surgery Department, Jincheng People's Hospital, 1666 BaiShui East Street, Jincheng, 048026, Shanxi, China. wyssxjc@163.com.

Keywords

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