AutoFRS: an externally validated, annotation-free approach to computational preoperative complication risk stratification in pancreatic surgery - an experimental study.

Journal: International journal of surgery (London, England)
Published Date: May 12, 2025

Abstract

BACKGROUND: The risk of postoperative pancreatic fistula (POPF), one of the most dreaded complications after pancreatic surgery, can be predicted from preoperative imaging and tabular clinical routine data. However, existing studies suffer from limited clinical applicability due to a need for manual data annotation and a lack of external validation. We propose AutoFRS (automated fistula risk score software), an externally validated end-to-end prediction tool for POPF risk stratification based on multimodal preoperative data.

Authors

  • Fiona R Kolbinger
    Department of Visceral, Thoracic and Vascular Surgery, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana.
  • Nithya Bhasker
    Division of Translational Surgical Oncology, National Center for Tumor Diseases (NCT), Partner Site Dresden, Dresden, Germany.
  • Felix Schön
    Faculty of Medicine and University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Institute and Polyclinic for Diagnostic and Interventional Radiology, Dresden, Germany.
  • Daniel Cser
    Division of Translational Surgical Oncology, National Center for Tumor Diseases (NCT), Partner Site Dresden, Dresden, Germany.
  • Alex Zwanenburg
    National Center for Tumor Diseases (NCT/UCC), Dresden, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.
  • Steffen Löck
    National Center for Tumor Diseases (NCT/UCC), Dresden, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.
  • Sebastian Hempel
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • André Schulze
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Nadiia Skorobohach
    Faculty of Medicine and University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Institute and Polyclinic for Diagnostic and Interventional Radiology, Dresden, Germany.
  • Hanna M Schmeiser
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Rosa Klotz
    Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.
  • Ralf-Thorsten Hoffmann
    Faculty of Medicine and University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Institute and Polyclinic for Diagnostic and Interventional Radiology, Dresden, Germany.
  • Pascal Probst
    Cantonal Hospital Thurgau, Frauenfeld, Switzerland.
  • Beat Müller
    Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.
  • Sebastian Bodenstedt
    Division of Translational Surgical Oncology, National Center for Tumor Diseases (NCT), Partner Site Dresden, Dresden, Germany.
  • Martin Wagner
    Department of Biology, Norwegian University of Science and Technology, 5 Høgskoleringen, 7491 Trondheim, Norway. Electronic address: martin.wagner@ntnu.no.
  • Jürgen Weitz
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Jens-Peter Kühn
    Faculty of Medicine and University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Institute and Polyclinic for Diagnostic and Interventional Radiology, Dresden, Germany.
  • Marius Distler
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Stefanie Speidel
    Division of Translational Surgical Oncology, National Center for Tumor Diseases (NCT), Partner Site Dresden, Dresden, Germany.

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