Exosomes derived from human umbilical cord mesenchymal stem cells attenuate senescence of peritoneal mesothelial cells by inhibiting oxidative stress.

Journal: International immunopharmacology
Published Date: May 11, 2025

Abstract

OBJECTIVE: Aging is a natural process that affects cellular function. In peritoneal dialysis (PD), chronic exposure to dialysate induces oxidative stress (OS) in peritoneal mesothelial cells (PMCs), leading to cellular aging, fibrosis, and reduced dialysis efficacy. Mesenchymal stem cells (MSCs) have shown potential in alleviating cellular aging. This study investigates the role of exosomes (hUMSC-Exos) derived from human umbilical cord MSCs (hUMSCs) in mitigating PMC senescence and explores the underlying mechanisms.

Authors

  • Jia Li
    Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan Tsuihang New District, Guangdong, 528400, PR China; School of Pharmacy, Zunyi Medical University, Zunyi, 563000, PR China; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, PR China.
  • Lixin Liu
    Departments of Geriatrics, The First Hospital of China Medical University, Shenyang, Liaoning 110001, PR China.
  • Yiman Chen
    Departments of Geriatrics, The First Hospital of China Medical University, Shenyang, Liaoning 110001, PR China.
  • Yuling Huang
    Departments of Geriatrics, The First Hospital of China Medical University, Shenyang, Liaoning 110001, PR China.
  • Lina Yang
    Departments of Geriatrics, The First Hospital of China Medical University, Shenyang, Liaoning 110001, PR China; Department of International Physical Examination Center, The First Hospital of China Medical University, Shenyang, Liaoning 110001, PR China. Electronic address: yanglina1984@163.com.

Keywords

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