Identification of neural crest and melanoma cancer cell invasion and migration genes using high-throughput screening and deep attention networks.

Journal: Developmental dynamics : an official publication of the American Association of Anatomists
Published Date: Jul 10, 2025

Abstract

BACKGROUND: Cell migration and invasion are well-coordinated in development and disease but remain poorly understood. We previously showed that the neural crest (NC) cell migratory wavefront shares a 45-gene panel with other cell invasion phenomena. To rapidly and systematically identify critical genes, we performed a high-throughput siRNA screen and statistical and deep learning analyses to determine changes in NC- versus non-NC-derived human cell line behaviors.

Authors

  • J C Kasemeier-Kulesa
    Stowers Institute for Medical Research, Kansas City, Missouri, USA.
  • S Martina Perez
    Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, UK.
  • R E Baker
    Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, UK.
  • P M Kulesa
    Children's Mercy Research Institute, Children's Mercy Hospital, Kansas City, Missouri, USA.

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