Pharmacokinetic and pharmacodynamic alterations in older people: what we know so far.

Journal: Expert opinion on drug metabolism & toxicology
Published Date: May 11, 2025

Abstract

INTRODUCTION: Healthcare professionals face increasing challenges when managing older patients, a group characterized by significant interindividual variability in comorbidity patterns, homeostatic capacity, frailty status, cognitive function, and life expectancy. Complex therapeutic decisions may increase the risk of inappropriate polypharmacy, drug-drug, and drug-disease interactions in the context of age-associated pharmacokinetic and pharmacodynamic alterations, with consequent drug accumulation and toxicity.

Authors

  • Arduino A Mangoni
    Discipline of Clinical Pharmacology, College of Medicine and Public Health, Flinders University, Adelaide, Australia.
  • Richard J Woodman
    Discipline of Biostatistics, College of Medicine and Public Health, Flinders University, Adelaide, Australia.
  • Elzbieta A Jarmuzewska
    Department of Internal Medicine, Polyclinic IRCCS, Ospedale Maggiore, University of Milan, Milan, Italy.

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