A systematic review and narrative summary of the therapeutic potential of classic serotonergic psychedelics for smoking cessation and reduction.

Journal: Journal of psychopharmacology (Oxford, England)
Published Date: Jul 11, 2025

Abstract

BACKGROUND: Classic serotonergic psychedelics are 5-HT2A partial agonists that induce non-ordinary states of consciousness. Many have demonstrated anti-addictive properties; however, their impact on smoking behaviors remains under-researched. This review provides a synthesis of the therapeutic potential of these compounds in promoting smoking cessation and reduction.

Authors

  • Dillon L Glenn
    College of Nursing, Wayne State University, Detroit, MI, USA.
  • Seung Hee Choi
    College of Nursing, Wayne State University, Detroit, MI, USA.
  • Rick S Zimmerman
    College of Nursing, Wayne State University, Detroit, MI, USA.

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