Prediabetes phenotypes: can aetiology and risk profile guide lifestyle strategies for diabetes prevention?
Journal:
Expert review of endocrinology & metabolism
Published Date:
Jul 12, 2025
Abstract
INTRODUCTION: Type 2 diabetes (T2D) continues to worsen globally alongside rise in obesity. Asymptomatic dysglycaemia, which precedes T2D, provides opportunities to identify those at risk and target prevention but prediabetes is highly variable. Not all with overweight develop dysglycaemia and not all with dysglycaemia are overweight. Important is the deposition of ectopic lipids in the pancreas, liver, and muscle. With no international definition, several prediabetes phenotypes exist, each based on one or more components of fasting glucose, postprandial glucose and/or HbA.
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