Impact of three-dimensional prostate models during robot-assisted radical prostatectomy on surgical margins and functional outcomes.

Journal: BJU international
Published Date: Jul 13, 2025

Abstract

BACKGROUND: Robot-assisted radical prostatectomy (RARP) is the standard surgical procedure for the treatment of prostate cancer. RARP requires a trade-off between performing a wider resection in order to reduce the risk of positive surgical margins (PSMs) and performing minimal resection of the nerve bundles that determine functional outcomes, such as incontinence and potency, which affect patients' quality of life. In order to achieve favourable outcomes, a precise understanding of the three-dimensional (3D) anatomy of the prostate, nerve bundles and tumour lesion is needed.

Authors

  • Nawal Khan
    School of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
  • Davide Prezzi
    School of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
  • Nicholas Raison
    Department of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
  • Andrew Shepherd
    Department of Urology, Guy's Hospital, London, UK.
  • Michela Antonelli
    Centre for Medical Image Computing, University College London, London, UK.
  • Nick Byrne
    Medical Physics and Clinical Engineering Department, Guy's and St Thomas' NHS Foundation Trust, London, UK.
  • Maia Heath
    Medical Physics and Clinical Engineering Department, Guy's and St Thomas' NHS Foundation Trust, London, UK.
  • Christopher Bunton
    Medical Physics and Clinical Engineering Department, Guy's and St Thomas' NHS Foundation Trust, London, UK.
  • Carlo Seneci
    3 Idrogenet Srl, Lumezzane, Italy.
  • Eoin Hyde
    Innersight Labs, London, UK.
  • Andres Diaz-Pinto
    Instituto de Investigación e Innovación en Bioingeniería, I3B, Universitat Politècnica de València, Camino de Vera s/n, 46022, Valencia, Spain. andiapin@upv.es.
  • Findlay Macaskill
    Responsible AI UK.
  • Benjamin Challacombe
    Department of Urology, Guy's and St Thomas' Hospitals NHS Foundation Trust and Kings College, London, UK.
  • Jonathan Noel
    Global Robotics Institute, Advent Health Celebration Health, Celebration, Florida, USA.
  • Christian Brown
    Higher Trainee in Forensic Psychiatry, South West London and St George's Mental Health NHS Trust, UK.
  • Ata Jaffer
    Guy's and St Thomas' NHS Foundation Trust, London, UK.
  • Paul Cathcart
    Department of Urology and Division of Surgery and Interventional Science, University College London Hospital, London, UK.
  • Margherita Ciabattini
    Unit of Urology, San Raffaele Hospital, Milan, Italy.
  • Armando Stabile
    Unit of Urology/Division of Oncology, Gianfranco Soldera Prostate Cancer Lab, URI, IRCCS San Raffaele Scientific Institute, Via Olgettina 58, 20132, Milan, Italy.
  • Alberto Briganti
    Unit of Urology/Division of Oncology, Gianfranco Soldera Prostate Cancer Lab, URI, IRCCS San Raffaele Scientific Institute, Via Olgettina 58, 20132, Milan, Italy.
  • Giorgio Gandaglia
    Unit of Urology/Division of Oncology, Gianfranco Soldera Prostate Cancer Lab, URI, IRCCS San Raffaele Scientific Institute, Via Olgettina 58, 20132, Milan, Italy.
  • Francesco Montorsi
    Unit of Urology/Division of Oncology, Gianfranco Soldera Prostate Cancer Lab, URI, IRCCS San Raffaele Scientific Institute, Via Olgettina 58, 20132, Milan, Italy.
  • Sébastien Ourselin
    Wellcome / EPSRC Centre for Interventional and Surgical Sciences (WEISS), University College London, UK.
  • Prokar Dasgupta
  • Alejandro Granados
    Surgical and Interventional Engineering, King's College London, London, UK. alejandro.granados@kcl.ac.uk.

Keywords

No keywords available for this article.

External Resources

Popular Topics
Recent Journals