Integrating bulk and single-cell RNA sequencing reveals intratumor heterogeneity phenotypes and immune infiltration in pancreatic cancer.

Journal: Discover oncology
Published Date: Jul 13, 2025

Abstract

BACKGROUND: Although the significance of intratumoral heterogeneity (ITH) has been widely acknowledged in various cancers, its role in pancreatic cancer (PC) remains underexplored and warrants further investigation.

Authors

  • Li Zhao
    International Initiative on Spatial Lifecourse Epidemiology (ISLE), the Netherlands; Department of Health Policy and Management, West China School of Public Health/West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, 610041, China; Research Center for Healthy City Development, Sichuan University, Chengdu, Sichuan, 610041, China; Healthy Food Evaluation Research Center, Sichuan University, Chengdu, Sichuan, 610041, China.
  • Yao Huang
    Department of Digestive Diseases, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.
  • Jiang Li
  • Rui Xie
    Department of Statistics and Data Science, University of Central Florida, Orlando, FL 32816 USA.
  • Kaiming Li
    Department of Pharmacy, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China. likaiming2016@126.com.

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