Identifying DNA methylation types and methylated base positions from bacteria using nanopore sequencing with multi-scale neural network.
Journal:
Bioinformatics (Oxford, England)
Published Date:
Jul 14, 2025
Abstract
MOTIVATION: DNA methylation plays important roles in various cellular physiological processes in bacteria. Nanopore sequencing has shown the ability to identify different types of DNA methylation from individual bacteria directly. However, existing methods for identifying bacterial methylomes showed inconsistent performances in different methylation motifs in bacteria and didn't fully utilize the different scale information contained in nanopore signals.
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