A diagnostic model based on transcriptomic analysis reveals inflammation as a potential prognosis factor for hepatoblastoma with hepatocellular carcinoma features.

Journal: Cellular oncology (Dordrecht, Netherlands)
Published Date: Jul 14, 2025

Abstract

INTRODUCTION: Hepatoblastoma (HB) with hepatocellular carcinoma (HCC) features (HBHF) is a rare liver malignancy. Due to its rarity and diverse histological presentations, the prognosis of HBHF remains controversial, and diagnostic differentiation poses significant challenges. To enable more accurate outcome evaluation and targeted therapeutic strategies, rapid, comprehensive, and cost-effective methods are needed to complement histopathological evaluation.

Authors

  • Yuhua Shan
    Department of Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 Dongfang Road, Shanghai Pudong District, Shanghai, 200127, P. R. China.
  • Min Zhang
    Department of Infectious Disease, The Second Xiangya Hospital of Central South University, Changsha, China.
  • Hongxiang Gao
    The State Key Laboratory of Bioelectronics, School of Instrument Science and Engineering, Southeast University, Nanjing, China.
  • Lei Zhang
    Division of Gastroenterology, Union Hospital, Tongji Medical College Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Chenjie Xie
    Department of Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 Dongfang Road, Shanghai Pudong District, Shanghai, 200127, P. R. China.
  • Jiquan Zhou
    Department of Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 Dongfang Road, Shanghai Pudong District, Shanghai, 200127, P. R. China.
  • Liyuan Yang
    College of Food Science and Technology, Nanjing Agricultural University, National Center of Meat Quality and Safety Nanjing, MOST, Key Laboratory of Meat Processing and Quality Control, MOE, Key Laboratory of Meat Processing, MOA, Nanjing 210095, China.
  • Ji Ma
    UCLA Henry Samueli School of Engineering and Applied Science, Los Angeles, USA.
  • Qiuhui Pan
    Clinical Laboratory, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, P. R. China.
  • Zhen Zhang
    School of Pharmacy, Jining Medical University, Rizhao, Shandong, China.
  • Min Xu
    Department of Gastroenterology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
  • Song Gu
    Department of Radiation Oncology, Hangzhou Yikang Chinese Medicine Oncology Hospital, Hangzhou, China.

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