A machine learning-assisted systematic review of preclinical glioma modeling: Is practice changing with the times?

Journal: Neuro-oncology advances
Published Date: Dec 28, 2024

Abstract

BACKGROUND: Despite improvements in our understanding of glioblastoma pathophysiology, there have been no major improvements in treatment in recent years. Animal models are a vital tool for investigating cancer biology and its treatment, but have known limitations. There have been advances in glioblastoma modeling techniques in this century although it is unclear to what extent they have been adopted.

Authors

  • Theodore C Hirst
    Department of Neurosurgery, Royal Victoria Hospital, Belfast, UK.
  • Emma Wilson
    Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
  • Declan Browne
    Department of Neurosurgery, Royal Victoria Hospital, Belfast, UK.
  • Emily S Sena
    Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.

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