Paediatric rare diseases: Can large language models assist off-label prescribing?

Journal: British journal of clinical pharmacology
Published Date:

Abstract

AIMS: To evaluate the effectiveness and reliability of large language models (LLMs) in retrieving and synthesizing biomedical information to support off-label drug prescribing in paediatric rare diseases, and to compare their performance with human-authored references in terms of scientific rationale, adverse events and drug interactions.

Authors

  • Anna Flamigni
    Institute for Maternal and Child Health (IRCCS Burlo Garofolo), Trieste, Italy.
  • Giulia Zamagni
    Institute for Maternal and Child Health (IRCCS Burlo Garofolo), Trieste, Italy.
  • Gilda Paternuosto
    Institute for Maternal and Child Health (IRCCS Burlo Garofolo), Trieste, Italy.
  • Anna Arbo
    Institute for Maternal and Child Health (IRCCS Burlo Garofolo), Trieste, Italy.

Keywords

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