Late gadolinium enhancement imaging and sudden cardiac death.

Journal: European heart journal
Published Date: Jul 16, 2025

Abstract

The prediction and management of sudden cardiac death risk continue to pose significant challenges in cardiovascular care despite advances in therapies over the last two decades. Late gadolinium enhancement (LGE) on cardiac magnetic resonance-a marker of myocardial fibrosis-is a powerful non-invasive tool with the potential to aid the prediction of sudden death and direct the use of preventative therapies in several cardiovascular conditions. In this state-of-the-art review, we provide a critical appraisal of the current evidence base underpinning the utility of LGE in both ischaemic and non-ischaemic cardiomyopathies together with a focus on future perspectives and the role for machine learning and digital twin technologies.

Authors

  • Sanjay K Prasad
    CMR Unit, Royal Brompton Hospital, Guy's and St Thomas's NHS Foundation Trust, Sydney Street, London, SW3 6NP, UK.
  • Tamim Akbari
    Royal Brompton and Harefield Hospitals, Part of Guy's and St Thomas' NHS Foundation Trust, CMR Unit, Sydney Street, London SW3 6NP, UK.
  • Martin J Bishop
    Biomedical Engineering & Imaging Sciences, King's College London, London SE1 7EH, United Kingdom.
  • Brian P Halliday
    National Heart and Lung Institute, Imperial College London, London, UK.
  • Francisco Leyva-Leon
    Aston Medical School, Translational Medicine Research Group (TMRG) College of Health and Life Sciences, Aston University, Birmingham B4 7ET, UK.
  • Francis Marchlinski
    Penn Heart and Vascular Center, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.

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