Cohort profile: China healthy aging cohort study (China-Aging).

Journal: Journal of Alzheimer's disease : JAD
Published Date: Jul 15, 2025

Abstract

BackgroundAs China undergoes a demographic transition towards an aging society, the prevalence and incidence of age-related disabilities, Alzheimer's disease, and various geriatric syndromes are steadily rising.ObjectiveThe China Healthy Aging Cohort Study (China-Aging) aims to investigate the prevalence and associated risk factors of disability and cognitive impairment, and to develop predictive models for these conditions by combining traditional risk factors with artificial intelligence-derived metrics (such as gait, speech, vision, etc.).MethodsThe China-Aging cohort consists of community-dwelling participants aged 60 years and older from Beijing, Hangzhou, Shenzhen, and Haikou. The baseline recruitment was from May 16, 2022 to March 19, 2025, with study participants primarily from urban areas. Follow-up assessment of the cohort will occur every 1-3 years from the baseline.ResultsAmong 6283 participants who completed the baseline evaluation (mean age 70.6 years, SD 6.3), 3775 (60.1%) were women. The overall prevalence of disability, cognitive impairment, frailty, depression, and sarcopenia were 17.8%, 18.5%, 5.9%, 7.1%, and 5.7%, respectively. The prevalence of disability in the Beijing cohort was higher than in other cohorts (Beijing: 35.6%, Hangzhou: 6.5%, Shenzhen: 6.8%, Haikou: 10.9%) and the prevalence of cognitive impairment in the Haikou cohort was higher than in other cohorts (Beijing: 9.5%, Hangzhou: 7.9%, Shenzhen: 16.2%, Haikou: 45.5%).ConclusionsThe prevalence of disability and cognitive impairment is relatively high, and notable regional difference exists in China. China-Aging cohort provides crucial evidence for the precise prevention and management of disability, cognitive impairment, and other geriatric syndromes in promoting active and healthy aging.

Authors

  • Jie Chang
    School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, China.
  • Yue Wu
    Key Laboratory of Luminescence and Real-Time Analytical Chemistry (Ministry of Education), College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China.
  • Yiwei Zhao
    Department of Bone and Joint Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  • Xue Gao
    Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China.
  • Yiwen Xing
    Department of Geriatrics, National Research Center for Geriatric Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.
  • Zhibin Wang
    School of Information and Communication Engineering, North University of China, Taiyuan 030051, China. wangzhibin@nuc.edu.cn.
  • Qi Qin
    Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Yantai Information Technology Research Institute of SJTU, Shanghai Engineering Research Center for Intelligent diagnosis and treatment instrument, Shanghai 200240, China. Electronic address: qinqi3591@sjtu.edu.cn.
  • Wenqing Ni
    Department of Elderly Health Management, Shenzhen Center for Chronic Disease Control, No.2021, Buxin Road, Shenzhen, Guangdong, 518020, China.
  • Yangwei Ying
    College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China.
  • Xiaoyan Liu
    College of Information Technology, Jilin Agricultural University, Changchun, China.
  • Lumin Leng
    Department of Neurology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
  • Hong Zhou
    Department of TCM Orthopedics & Traumatology, Gansu province hospital of TCM, Lanzhou, China.
  • Lina Ma
    c BIG Data Center, Beijing Institute of Genomics (BIG) , Chinese Academy of Sciences , Beijing , China.
  • Yansu Guo
    Beijing Geriatric Healthcare and Disease Prevention Center, Xuanwu Hospital, Capital Medical University, Beijing, China.
  • Guoping Peng
    Department of Neurology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
  • Yong You
    The Fourth People's Hospital of Shenyang, Shenyang, 110034, China.
  • Jindong Ding Petersen
    Department of Neurology, the Second Affiliated Hospital of Hainan Medical University, Haikou, China.
  • Jian Xu
    Department of Cardiology, Lishui Central Hospital and the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, China.
  • Yi Tang
    Department of Nephrology, Institute of Nephrology, West China Hospital of Sichuan University, Chengdu, China.

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