Integrating multi-omics and machine learning strategies to explore the "gene-protein-metabolite" network in ischemic heart failure with Qi deficiency and blood stasis syndrome.

Journal: Chinese medicine
Published Date:

Abstract

BACKGROUND: Ischemic heart failure (IHF) is a multifaceted syndrome associated with significant mortality and high hospitalization rates globally. According to traditional Chinese medicine (TCM) theory, Qi Deficiency and Blood Stasis (QXXY) Syndrome serves as the pathological basis of IHF. This study aims to investigate the biological basis of QXXY syndrome in IHF patients through an integrated multi-omics approach.

Authors

  • Jingjing Wei
    Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center; State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai, 200438, China.
  • Aolong Wang
    Department of Cardiovascular Disease, The First Affiliated Hospital of Henan University of Chinese Medicine, Renmin Road 19, Jinshui District, Zhengzhou, 450000, China.
  • Peng Yu
    College of Life Science, Northwest Normal University, Lanzhou, 730070, Gansu, People's Republic of China.
  • Yang Sun
    Department of Gastroenterology, First Affiliated Hospital of Kunming Medical University, Kunming, China.
  • Wenjun Wu
    Department of Medical Education and Biomedical Informatics, University of Washington, Seattle, WA.
  • Yilin Zhang
    Department of Preventive Medicine, School of Public Health, Fujian Medical University; and Key Laboratory of Environment and Health, Fujian Province University, 1 North Xue-Fu Rd, Minhou, Fuzhou, 350122, Fujian Province, China.
  • Rui Yu
    Beijing Institute of Biotechnology, 20 Dongdajie Street, Fengtai District, Beijing, China.
  • Bin Li
    Department of Magnetic Resonance Imaging (MRI), Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
  • Mingjun Zhu
    Department of Cardiovascular Disease, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, 450000, Henan, China. zhumingjun317@163.com.

Keywords

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