Identification and evaluation of metabolic mRNAs and key miRNAs in colorectal cancer liver metastasis.

Journal: Cancer cell international
Published Date: Jul 16, 2025

Abstract

BACKGROUND: Colorectal cancer (CRC) represents a major global health challenge due to its high lethality, largely attributable to liver metastasis. Despite the established correlation between metabolic reprogramming of cancer cells and their proliferation, invasion, and metastasis, the specific role of metabolism-associated mRNAs in the liver metastasis of CRC remains unelucidated.

Authors

  • Guanxuan Chen
    The Key Laboratory of Biomarker High throughput screening and target translation of breast and gastrointestinal tumor, Affiliated Zhongshan Hospital of Dalian University, No.6 Jiefang Street, Zhongshan District, Dalian, 116001, Liaoning, China.
  • Shiwen Wang
    State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
  • Meng Zhang
    College of Software, Beihang University, Beijing, China.
  • Wenna Shi
    Department of Pharmacy, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, Shandong, PR China.
  • Ruoyu Wang
    Institute of Public Health and Wellbeing, University of Essex, Essex, UK.
  • Wanqi Zhu
    Department of Research and Education, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, 440 Ji-Yan Road, Jinan, 250117, Shandong Province, PR China. zhuwanqi@sdfmu.edu.cn.

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