Impact of environmental pollution on human health: Investigating the role of Polycyclic Aromatic Hydrocarbons in pediatric osteosarcoma.

Journal: Ecotoxicology and environmental safety
Published Date: Jul 19, 2025

Abstract

BACKGROUND: Polycyclic aromatic hydrocarbons (PAHs), widely emitted through industrial processes and vehicular exhaust, are recognized environmental carcinogens. Although PAH exposure has been linked to various malignancies, the specific molecular mechanisms underlying its involvement in pediatric osteosarcoma remain poorly defined.

Authors

  • Mingxian Xu
    Department of Musculoskeletal Oncology, The First Affiliated Hospital of Sun Yat-sen University, No.58 Zhongshan 2 Road, Guangzhou 510080, China; Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, The First Affiliated Hospital of Sun Yat-sen University, No.58 Zhongshan 2 Road, Guangzhou 510080, China. Electronic address: xumx8@mail2.sysu.edu.cn.
  • Yu Xu
    Panzhihua Central Hospital, Panzhihua, Sichuan, China.
  • Yaping Huang
    School of Resources and Geosciences, China University of Mining and Technology, Xuzhou, China.
  • Jixiang Shi
    Department of Musculoskeletal Oncology, The First Affiliated Hospital of Sun Yat-sen University, No.58 Zhongshan 2 Road, Guangzhou 510080, China; Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, The First Affiliated Hospital of Sun Yat-sen University, No.58 Zhongshan 2 Road, Guangzhou 510080, China.
  • Lifeng Yin
    Department of Musculoskeletal Oncology, The First Affiliated Hospital of Sun Yat-sen University, No.58 Zhongshan 2 Road, Guangzhou 510080, China; Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, The First Affiliated Hospital of Sun Yat-sen University, No.58 Zhongshan 2 Road, Guangzhou 510080, China.
  • Jian Tu
    Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, Hunan 421001, P.R. China.
  • Junqiang Yin
    Department of Musculoskeletal Oncology, The First Affiliated Hospital of Sun Yat-sen University, No.58 Zhongshan 2 Road, Guangzhou 510080, China; Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, The First Affiliated Hospital of Sun Yat-sen University, No.58 Zhongshan 2 Road, Guangzhou 510080, China. Electronic address: yinjunq@mail.sysu.edu.cn.
  • Changye Zou
    Department of Musculoskeletal Oncology, The First Affiliated Hospital of Sun Yat-sen University, No.58 Zhongshan 2 Road, Guangzhou 510080, China; Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, The First Affiliated Hospital of Sun Yat-sen University, No.58 Zhongshan 2 Road, Guangzhou 510080, China. Electronic address: zouchy@mail.sysu.edu.cn.

Keywords

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